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Exactly how soy protein has this effect is still not known although researchers propose several mechanisms. It may work by enhancing bile acid secretion, which has the effect of removing cholesterol from the blood.
Another suggestion is that soy protein stimulates the liver to remove LDL cholesterol from the blood or that the isoflavones in soy may act either as antioxidants or in helping blood vessels dilate, thus reducing damage to LDL cholesterol and its build-up on artery walls.
Whichever theory proves to be correct, when it comes to isoflavones, it is not just the heart that they are potentially capable of protecting.
Seen by some experts as the secret weapon of the soybean, isoflavones along with lignans found in this legume are known to have structural similarities to the human hormone oestrogen.
During a woman’s reproductive years, one of the risk factors for developing breast cancer and other hormonally dependent cancers of the ovaries and endometrium appears to be over-exposure to human oestrogen.
Capable of latching on to so called beta oestrogen receptors in breast, ovarian and endometrial cells, large amounts of oestrogen may cause the cells to divide and then replicate in an uncontrolled manner - the process we call cancer.
The beauty of the plant oestrogens found in soy is that their similar shape and structure to human oestrogen means they can fit into beta oestrogen receptors, yet because they are much weaker than human oestrogen, they appear to be able to reduce the risk of initiating the cell division process.
Dr Michael Morton, senior scientist at the BioClinical Research Services Laboratory in Wales, UK, helps to put this action into perspective: “A recent report demonstrated that in laboratory studies, genistein, the main isoflavone plant oestrogen in soy, binds to beta oestrogen receptors similar to tamoxifen, a drug used to help prevent and treat women with breast cancer.”
Genistein also seems to have powerful effects on cell growth and regulation, helping to inhibit the action of enzymes needed for cell division as well as preventing the formation of new blood vessels to cancerous cells.
The benefits of soy do not end there. For pre-menopausal women the plant oestrogens in soy seem to help dampen down the effects of human oestrogen.
For post-menopausal women, any oestrogenic effect, albeit a weak one, can be helpful for reducing both short and long term effects of menopause.
References
Meta-analysis of effects of soy protein intake on serum lipids in humans. Anderson JW et al. New England Journal of Medicine. 1995; 333(5): 276-282.
Effects of soy isoflavones on oestrogen and phytooestrogen metabolism in premenopausal women. Xu X et al. Cancer Epidemiology, Biomarkers and Prevention: vol. 7, 1101 - 1108, 1998.
The effect of dietary soy supplementation on hot flushes. Albertazzi P et al. Obstetrics and Gynecology: vol. 91, No.1, January 1998.
soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Potter S et al. American Journal of Clinical Nutrition: 1998; 68 (supl):1375s - 9s.
Setchell K.D, Cassidy A Dietary isoflavones: biological effcts and relevance to human health. Jnutr. 1999; 129:758S-767S.
References: European Food Information Council (EUFIC)
Date last updated: 15 November 2006
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